Proceeding of Mulawarman Pharmaceuticals Conferences
type: channel
description: Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.) Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.) published by Fakultas Farmasi, Universitas Mulawarman with ISSN 2614-4778. This proceeding publishes article as result seminar regularly two times per year held by Faculty of Pharmacy, University of Mulawarman since 2015. Initially, this proceeding called “Prosiding Seminar Nasional Kefarmasian” and it changes become Proceeding Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.) in 2017. Mulawarman Pharmaceuticals Conference can hold by either Faculty of Pharmacy, University of Mulawarman or corporate with professional organization/association or other institute. Proceeding of Mulawarman Pharmaceuticals Conferences is open access. Proceeding of Mulawarman Pharmaceuticals Conference is indexed by: Article Template Article Template of Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.) based on Article template of Jurnal Sains dan Kesehatan is published by Fakultas Farmasi Universitas Mulawarman Jurnal Famul: 1. Journal of Tropical Pharmacy and Chemistry (J. Trop. Pharm. Chem.) 2. Jurnal Sains dan Kesehatan (J. Sains. Kes.) 3. Proceeding of Mulawarman Pharmaceuticals Conferences(Proc. Mul. Pharm. Conf.) Perubahan Domain Jurnal Sehubungan dengan maraknya hack atau penyusupan situs judi dan pinjaman online pada website/situs pemerintah menyebabkan kinerja website yang disusupi menjadi kurang maksimal. Salah satu website yang sering disusupi adalah website jurnal karena banyaknya interaksi atau kunjungan user pada website tersebut menyebabkan situs jurnal tidak dapat diakses karena dilakukan pemblokiran oleh pemerintah. Oleh karena itu untuk menghindari adanya penyusupan situs judi online tersebut maka kami melakukan perubahan website jurnal. Adapun perubahan yang dimaksud adalah sebagai berikut: 1. Journal of Tropical Pharmacy and Chemistry p-ISSN: 2087-7099 e-ISSN: 2407-6090…
publisher: Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
language: en-US
publication name: Proceeding of Mulawarman Pharmaceuticals Conferences
issn: 2614-4778
items: Profil Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Kulit Buah Nanas (Ananas comosus (L.) Merr)
items: Analisis Karakteristik Dismenore pada Remaja Putri
items: Pengaruh Kemoterapi terhadap Kadar Hematologi pada Pasien Kanker Payudara di RSUD dr. Kanujoso Djatiwibowo Balikpapan
items: Skrining Fitokimia dan Optimasi Basis Spray Gel Ekstrak Etanol Kulit Bawang Putih (Allium sativum L.) sebagai Anti Jerawat
items: Formulasi Sediaan Lip cream Ekstrak Etanol Bunga Asoka (Ixora coccinea) sebagai Pewarna Alami
items: Analisis Kadar Flavonoid Total Ekstrak Etanol Daun Kelakai Merah (Stenochlaena palustris (Burm F.) Bedd) Berbantu Ultrasonik
items: Pola Pengobatan pada Pasien Malaria di Rumah Sakit Umum Daerah (RSUD) Timika, Kabupaten Mimika
items: Hubungan Pelayanan Informasi Obat dengan Pengetahuan dan Tingkat Kepatuhan Pasien Hipertensi di Puskesmas Kerang Kecamatan Batu Engau
items: Uji Aktivitas Mukolitik dari Ekstrak Etanol Daun Sirsak (Annona muricata Linn) Menggunakan Mukosa Usus Sapi Secara In Vitro
items: Formulasi Sediaan Sabun Cair Ekstrak Etanol Daun Afrika (Vernonia Amygdalina Delile) dan Aktivitas Antibakterinya
items: Pengaruh Kemasan Penyimpanan terhadap Kadar Senyawa Non Spesifik Kemangi (Ocimum basilicum L.) pada Suhu Tertentu
items: Uji Efek Antidiare Ekstrak Rimpang Kunyit Hitam (Curcuma caesia Roxb.) terhadap Mencit (Mus musculus)
items: Formulasi Sediaan Serum Wajah dari Ekstrak Sarang Burung Walet
items: Efek Beta Sitosterol dan Kunyit Hitam (Curcuma caesia) Terhadap Berat Badan dan Abnormalitas Hati pada Mencit (Mus musculus) yang Diinduksi Etanol
items: Profil Kromatografi Lapis Tipis Antioksidan Tumbuhan Gulma: Axonopus compressus (Sw.) P. Beauv and Digitaria ciliaris (Retz.) Koeler
items: Penentuan Nilai Sun Protection Factor (SPF) Ekstrak Etanol Rimpang Kunyit Hitam (Curcuma caesia ROXB.) dengan Metode Spektrofotometri UV-Vis
items: Karakteristik Ekstrak Daun Kersen (Muntingia calabura L.) sebagai Kandidat Bahan Aktif dalam Formulasi Gel Sleeping Mask
items: Skrining Fitokimia dan Karakterisasi Minyak Biji Kemiri (Aleurites moluccana L.)
items: Validasi Metode dan Penetapan Kadar Kafein Menggunakan Spektrofotometri UV-Vis
items: Optimasi Pembuatan Nanopartikel Ekstrak Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) Berdasarkan Konsentrasi Kitosan
items: Skrining Fitokimia dan Pengujian Toksisitas Ekstrak Etanol Buah Mangrove (Sonneratia ovata) dengan Metode Brine Shrimp Lethality Test (BSLT)
items: Kajian Metabolit Sekunder dan Potensi Antibakteri Daun Banitan (Monocarpia kalimantanensis)
items: Karakteristik Teh Herbal Daun Kersen (Muntingia calabura L.) dan Daun Salam (Syzygium polyanthum) Sebagai Antioksidan
items: Pengaruh Beberapa Variasi Konsentrasi Kitosan Terhadap Potensial Zeta Nanopartikel Ekstrak Bawang Dayak (Eleutherine bulbosa)
items: Isolasi dan Karakterisasi Jamur Endofit Daun Belimbing Hutan (Cnestis palala (Lour.) Merr)
items: Aktivitas Antimikroba Ekstrak dan Fraksi Kulit Batang Banitan (Monocarpia kalimantanensis)
items: Identifikasi Potentially Inappropriate Medication (PIM’s) Menggunakan Kriteria Beers dan STOPP pada Pasien Geriatri dengan Diagnosis Gastrointestinal Rawat Inap di RSUD Abdul Wahab Sjahranie Samarinda
items: Evaluasi Penggunaan Obat pada Pasien Artritis Gout di Instalasi Rawat Jalan Rumah Sakit Pupuk Kaltim Bontang Periode 2022
items: Observasi Klinik Penggunaan Obat Sariawan pada Remaja
items: Uji Aktivitas Antioksidan Berdasarkan Perbedaan Tingkat Kematangan Buah Alpukat (Persea americana Mill.) Menggunakan Metode DPPH
items: Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Daun Cabai Rawit (Capsiccum frutescens L.) terhadap Staphylococcus epidermidis
items: Skrining Fitokimia dan Uji Aktivitas Tabir Surya Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.)
items: Level of Knowledge, Attitudes and Behavior towards Antibiotic Resistance and Use in The Community in Kota Bangun Seberang Village
items: Laporan Kasus: Epilepsi pada Wanita Muda

Profil Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Kulit Buah Nanas (Ananas comosus (L.) Merr)
type: item
description: Pineapple (Ananas comosus (L.) Merr) is one of the plants that is widely consumed by the public. However, the use of pineapple fruit is mostly for the flesh of the fruit, while the skin of the fruit is thrown away and becomes waste. In fact, pineapple skin contains many chemical compounds that can be used because they have properties. The aim of this research was to determine the secondary metabolite compounds and antibacterial activity of pineapple peel. The results showed that pineapple peel extract was positive for containing flavonoids, alkaloids, tannins and phenolics, while the negative results contained saponins, steroids and triterpenoids. Pineapple peel extract has moderate to very strong antibacterial activity with the diameter of the inhibition zone at concentrations of 5%, 10%, 15% and 20% respectively being 11.69; 14.88; 17.51; 22.01 mm against Staphylococcus aureus bacteria and 9.79;13.09;16.48;18.46 mm against Propionibacterium acnes bacteria. Keywords: Pineapple peel, antibacterial, Staphylococcus aureus, Propionibacterium acnes Abstrak Buah Nanas (Ananas comosus (L.) Merr) adalah salah satu tanaman yang banyak dikonsumsi oleh masyarakat. Namun pemanfaatan buah nanas lebih banyak pada daging buahnya saja sedangkan kulit buahnya dibuang dan menjadi limbah. Padahal di dalam kulit buah nanas banyak terkandung senyawa kimia yang dapat dimanfaatkan karena memiliki khasiat. Tujuan penelitian ini adalah untuk mengetahui senyawa metabolit sekunder dan aktivitas antibakteri dari kulit buah nanas. Hasil penelitian menunjukkan ekstrak kulit buah nanas positif mengandung flavonoid, alkaloid, tanin dan fenolik, sedangkan hasil negatif mengandung saponin, steroid dan triterpenoid. Ekstrak kulit buah nanas memiliki aktivitas antibakteri dengan kategori sedang hingga sangat kuat dengan diameter zona hambat pada konsentrasi 5%, 10%, 15% dan 20% secara berturut-turut adalah 11,69;14,88;17,51;22,01 mm terhadap bakteri Staphylococcus aureus dan 9,79;13,09;16,48;18,46 mm…
creator: Aisyah Mursidah
creator: Supriatno Salam
creator: Risna Agustina
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 1
ending page: 6
doi: 10.25026/mpc.v18i1.695

Analisis Karakteristik Dismenore pada Remaja Putri
type: item
description: Menstrual pain or dysmenorrhea is pain felt during menstruation so that it can interfere with a woman's daily activities. Usually women experience discomfort during menstruation, such as cramps and are usually accompanied by nausea and dizziness. The aim of this research is to determine the characteristics of young women who experience dysmenorrhea at SMKN 1 Muara Bengkal. This research is descriptive in nature with an observation method. It was found that the incidence of dysmenorrhea occurred most frequently in respondents who were 16 years old at 36.67%, at menarche age 12-13 years at 63.33%, with a duration of menstrual pain of 1 day at 40.00%, respondents did not take care of the pain. amounted to 66.67%, respondents with symptoms of dizziness amounted to 60.00%, and it was found that 76.67% of respondents said that menstrual pain could affect activities. So it can be concluded that there is no relationship between age, age of menarche, duration of menstrual pain, treatment during menstrual pain, other symptoms during dysmenorrhea which can influence the occurrence of dysmenorrhea. Keywords: Menstruation, dysmenorrhea, menstrual pain, teenage girls Abstrak Nyeri haid atau dismenore adalah nyeri yang dirasakan pada saat menstruasi sehingga dapat mengganggu aktifitas sehari-hari wanita. Biasanya wanita mengalami rasa yang tidak nyaman pada saat menstruasi, seperti keram dan biasanya disertai mual dan pusing. Tujuan penelitian ini untuk mengetahui gambaran karakteristik remaja putri yang mengalami dismenore di SMKN 1 Muara Bengkal. Penelitian ini bersifat deskriptif dengan metode observasi. Diperoleh hasil kejadian dismenore paling banyak terjadi pada responden yang memiliki 16 tahun sebesar 36,67%, memiliki usia menarche 12-13 tahun sebesar 63,33%, dengan durasi nyeri haid 1 hari sebesar 40,00%, responden tidak melakukan penanganan saat nyeri sebesar 66,67%, responden dengan gejala pusing sebesar 60,00%, dan didapatkan responden sebesar 76,67% mengatakan bahwa ny…
creator: Alfenia Rahmayanti
creator: Fahriani Iatiqamah Jafar
creator: Laode Rijai
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 7
ending page: 11
doi: 10.25026/mpc.v18i1.696

Pengaruh Kemoterapi terhadap Kadar Hematologi pada Pasien Kanker Payudara di RSUD dr. Kanujoso Djatiwibowo Balikpapan
type: item
description: Breast cancer is a malignant disease of breast tissue that can originate from the duct epithelium or lobules. Breast cancer therapy can be done with several types of therapy, one of which is chemotherapy. The most common side effect of chemotherapy is myelosuppression, a decrease in blood cell levels because chemotherapy agents are toxic to blood-forming organs. This research was conducted to understand the effect of chemotherapy in reducing blood cell levels in breast cancer patients who received chemotherapy at RSUD dr. Kanujoso Djatiwibowo Balikpapan for the period July 2022 to June 2023. This research is descriptive with a cross-sectional design. Of the 82 samples, 50 patients (60%) had erythrocyte levels below normal; hemoglobin in 79 patients (96%); hematocrit in 75 patients (91%); neutrophils in 20 patients (24%); leukocytes in 25 patients (30%); and thrombocytes in 7 patients (9%). The most common hematological levels below normal are hemoglobins and hematocrits. Keywords: ca mamae, hematology, mielosuppresion Abstrak Kanker payudara merupakan penyakit keganasan pada jaringan payudara yang dapat berasal dari epitel duktus maupun lobulusnya. Terapi kanker payudara dapat dilakukan dengan beberapa macam terapi, salah satunya adalah kemoterapi. Efek samping kemoterapi yang paling umum adalah mielosupresi yaitu penurunan kadar sel darah karena agen kemoterapi bersifat toksik terhadap organ pembentuk darah. Penelitian ini dilakukan untuk mengetahui gambaran pengaruh kemoterapi dalam menurunkan kadar sel darah pasien kanker payudara yang menerima kemoterapi di RSUD dr. Kanujoso Djatiwibowo Balikpapan periode Juli 2022 sampai Juni 2023. Penelitian ini bersifat deskriptif dengan desain cross-sectional. Dari 82 sampel, pasien dengan kadar eritrosit dibawah normal sebanyak 50 pasien (60%); hemoglobin 79 pasien (96%); hematokrit 75 pasien (91%); neutrofil 20 pasien (24%); leukosit 25 pasien (30%); dan trombosit 7 pasien (9%). Kadar hematologi di bawah normal paling bany…
creator: Annisa Nabilah
creator: Wisnu Cahyo Prabowo
creator: Hadi Kuncoro
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 12
ending page: 17
doi: 10.25026/mpc.v18i1.697

Skrining Fitokimia dan Optimasi Basis Spray Gel Ekstrak Etanol Kulit Bawang Putih (Allium sativum L.) sebagai Anti Jerawat
type: item
description: Spray gel is topical pharmaceutical preparations that can last long when sprayed on the skin. Because without physical contact, this preparation can reduce waste and the risk of developing skin diseases. The purpose of this study are determine the secondary metabolite content of garlic skin extract and obtain the optimal spray gel base. This study begins with the extraction of samples using 70% ethanol. Then qualitative phytochemical screening was conducted. Spray gel base optimization was carried out by varying the concentration of carbopol where F1(0,1%), F2(0,2%) and F3(0,3%) were then evaluated. The results of this study are garlic skin extract contains alkaloids, flavanoids, saponins and tannins. While the results of the base evaluation are in the organoleptic test all bases form are slightly cloudy in color, odorless and liquid, not sticky and has no air bubbles. All base formulas have been homogeneous, attached and spread, the range of the pH are 8.67-9.80 and the results of the viscosity test is range of average viscosity are 33.33-780 dPa.s. In this study, it can be concluded that garlic skin extract contains alkaloid, flavanoid, saponin and tannin that have potential as anti acne and the optimum carbopol concentration for spray gel base is 0,2%. Keywords: Phytochemical Screening, Allium sativum L., Spray Gel, Anti Acne Abstrak Spray gel termasuk kedalam sediaan topikal farmasi yang dapat bertahan lama ketika disemprotkan pada kulit, karna tanpa adanya kontak fisik sediaan ini dapat mengurangi limbah dan risiko terkena penyakit kulit seperti jerawat. Tujuan dari penelitian ini adalah untuk mengetahui kandungan metabolit sekunder dari ekstrak etanol kulit bawang putih dan mendapatkan basis optimal spray gel. Penelitian ini diawali dengan ekstraksi sampel menggunakan pelarut etanol 70%. Kemudian dilakukan skrining fitokimia secara kualitatif. Optimasi basis spray gel dilakukan dengan memvariasikan konsentrasi bahan pembentuk gel (karbopol) dimana F1(0,1%), F2…
creator: Brilian Dwisaputra Bandu
creator: Maria Almeida
creator: Laode Rijai
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 18
ending page: 23
doi: 10.25026/mpc.v18i1.698

Formulasi Sediaan Lip cream Ekstrak Etanol Bunga Asoka (Ixora coccinea) sebagai Pewarna Alami
type: item
description: Asoka flower (Ixora coccinea) possesses pigments that can be used as natural colorants in decorative cosmetics. The use of natural colorants in decorative cosmetics is still limited and the demand for decorative cosmetics especially lip cream is increasing. This research aims to determine whether ethanol extract of Asoka flowers can be used as an alternative natural colorant in lip cream formulations. This research began with extraction of Asoka flowers using maceration method with 96% ethanol solvent and citric acid. Base was optimized using a single thickener and combination of carnauba wax and candelilla wax. Base was evaluated and formulated with flower extract. The formulation quality was determined through organoleptic, homogeneity, spreadability, adhesion, viscosity, and pH tests. The extraction results yielded a yield of 27,1%. Best base was bases F3, F4, and F5. Formulations using Asoka flower extract with 2%, 4%, and 6% produced sequentially light brown, reddish-brown, and red colors. F3 produces the best color at pH 4.6. The evaluation results include the distinctive aroma of chocolate, semi-solid consistency, homogeneity, spreadability, adhesion, viscosity, and pH that meet the pharmaceutical requirements. In conclusion, ethanol extract from Asoka flowers can be utilized as a natural colorant in lip cream formulations. Keywords: Ixora coccinea, Natural Colorants, Lip cream, Carnauba wax, Candelilla wax Abstrak Bunga asoka (Ixora coccinea) memiliki pigmen warna yang dapat digunakan sebagai pewarna alami pada kosmetik dekoratif. Namun penggunaan pewarna alami pada kosmetik dekoratif masih kurang dan permintaan penggunaan kosmetik dekoratif terutama lip cream semakin meningkat. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol bunga asoka dapat digunakan sebagai alternatif pewarna alami pada sediaan lip cream. Penelitian ini diawali dengan ekstraksi bunga asoka dengan metode maserasi dengan pelarut etanol 96% dan asam sitrat. Lalu dilakukan op…
creator: Chintiya Vera Nanda
creator: Dwi Elfira Kurniati
creator: Niken Indriyanti
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 24
ending page: 32
doi: 10.25026/mpc.v18i1.699

Analisis Kadar Flavonoid Total Ekstrak Etanol Daun Kelakai Merah (Stenochlaena palustris (Burm F.) Bedd) Berbantu Ultrasonik
type: item
description: Kelakai merah is a typical plant of Kalimantan that is widely used for medicinal purposes. This plant is reported to contain numerous secondary metabolite compounds, including phenolic and flavonoid compounds. This research aims to determine the flavonoid content of the ethanol extract of red kelakai leaves (Stenochlaena palustris (Burm F.) Bedd) extracted using ultrasonic assistance. Ultrasonic-assisted extraction was carried out with variations in time (5, 10, 15, 20, and 25 minutes) and temperature (20, 30, 40, 50, and 60°C). The extract obtained during the ultrasonic-assisted extraction process was then measured for flavonoid content using the spectrophotometry method. The research results showed the highest yield of the extraction process at a temperature variation of 60°C with a time of 20 minutes (20%). The highest flavonoid content was obtained at a temperature variation of 50°C with a time of 25 minutes (51.86 ppm quercetin in 100 mg of extract). This study provides evidence that ultrasonication can be used as an effective method for extracting total flavonoids from red kelakai leaves, which have the potential for applications in the development of herbal and pharmaceutical products based on this plant material. Keywords: Kelakai merah, Extraction, Ultrasonic, Flavonoid Abstrak Kelakai merah merupakan tanaman khas kalimantan yang banyak digunakan sebagai obat. Tanaman ini dilaporkan memiliki banyak kandungan senyawa metabolit sekunder diantaranya senyawa golongan fenolik dan flavonoid. Penelitian ini bertujuan untuk mengetahui kadar flavonoid dari ekstrak etanol daun kelakai merah (Stenochlaena palustris (Burm F.) Bedd) yang diekstraksi dengan menggunakan bantuan gelombang ultrasonik. Ekstraksi berbantu ultrasonik dilakukan dengan variasi waktu (5, 10, 15, 20 dan 25 menit) dan suhu (20, 30, 40, 50 dan 60°C). Ekstrak yang diperoleh pada proses ekstraksi berbantu ultrasonik kemudian diukur kadar flavonoid menggunakan metode spektrofotometri. Hasil penelitian …
creator: Chisilia Brydhita Karangan
creator: Wisnu Cahyo Prabowo
creator: Risna Agustina
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 33
ending page: 38
doi: 10.25026/mpc.v18i1.700

Pola Pengobatan pada Pasien Malaria di Rumah Sakit Umum Daerah (RSUD) Timika, Kabupaten Mimika
type: item
description: Malaria is a contagious disease caused by the parasite Plasmodium (class Sporozoa) which attacks red blood cells in the human body, malaria is very high in endemic areas, one of which is in Papua Province, especially in Mimika Regency. This study aims to determine the characteristics and treatment patterns in inpatient malaria patients at Timika Hospital, Mimika Regency in the January-December 2022 period. The method used in the study was a descriptive non-experimental study with retrospective data collection of 100 medical record data of hospitalized malaria patients who met the inclusion criteria. The results showed that the male sex was more dominant than women with a total of 53 people. At the most dominant age, namely the age of 12-25 years, malaria becomes dominant with 25 people. Then in the most dominant job, namely students, became the main target of malaria infection as many as 25 people. Falciparum (tropical) malaria became dominant because the most cases of falsiparum malaria in Papua were 52 people. DHP (Dihydroartemisinin-piperaquine) treatment as many as 94 people, and artesunate as many as 98 people. For drug administration, proper dosage, and time administration, all in accordance with the management of the Ministry of Health. Keywords: Treatment pattern, patient Characteristics Abstrak Malaria merupakan penyakit yang menular disebabkan oleh parasit Plasmodium (kelas Sporozoa) yang menyerang sel darah merah pada tubuh manusia, malaria sangat tinggi di daerah endemik salah satunya dipropinsi papua kususnya dikabupaten mimika. Penelitian ini bertujuan untuk mengetahui karakteristik dan pola pengobatan pada pasien malaria rawat inap RSUD Timika Kab.Mimika pada periode januari-desember 2022. Metode yang digunakan pada penelitian yaitu studi non eksperimental secara deskriptif dengan pengambilan data secara retrospektif terhadap 100 data rekam medik pasien malaria rawat inap yang memenuhi kriteria inklusi. Hasil penelitian menunjukan bahwa pada jenis kel…
creator: Christin Claritha Mote
creator: Sabaniah Indjar Gama
creator: Yurika Sastyarina
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 39
ending page: 44
doi: 10.25026/mpc.v18i1.701

Hubungan Pelayanan Informasi Obat dengan Pengetahuan dan Tingkat Kepatuhan Pasien Hipertensi di Puskesmas Kerang Kecamatan Batu Engau
type: item
description: The World Health Organization (WHO) states that hypertension is an increase in systolic pressure greater than or equal to 160 mmHg and/or diastolic pressure equal to or greater than 95 mmHg. According to data obtained from the Kerang health center for the 2022-2023 period, the total prevalence at the health center was 5,393 with a total population of 12,902. One way to overcome hypertension is to increase patient knowledge and compliance with treatment by providing Drug Information Services. The aim of this research is to determine the characteristics, knowledge and level of compliance, determine drug information services and determine the relationship between drug information services and the knowledge and level of compliance of hypertensive patients. The method used is observational analysis with data collection using a prospective approach using medical record data and interview results. The results of the research on the characteristics of the majority of patients were in the late adult phase, 25.4%, 70.1% were female, 59.7% had elementary school education and 64% worked as housewives. The level of compliance of hypertensive patients is still low with a percentage of 59.80% and the level of knowledge of hypertensive patients is also in the low category with a percentage of 52.24%. Drug information services that are often provided only include the name of the drug, preparation, dosage, how to use, storage and side effects. and a significant value was obtained for the Knowledge Level with a correlation value of 0.344 and the Compliance Level with a correlation value of 0.649. Keywords: Hypertension; Drug Information Services; Compliance and Knowledge Abstrak Salah satu cara untuk menanggulangi hipertensi adalah meningkatkan pengetahuan dan kepatuhan pasien dalam pengobatan dengan cara pemberian Pelayanan Informasi Obat. Tujuan penelitian ini untuk mengetahui karakteristik, pengetahuan dan tingkat kepatuhan, mengetahui pelayanan informasi obat serta mengetahui hubu…
creator: Dayuh Anggun Mandalika
creator: Herman Herman
creator: Nisa Naspiah
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 45
ending page: 50
doi: 10.25026/mpc.v18i1.702

Uji Aktivitas Mukolitik dari Ekstrak Etanol Daun Sirsak (Annona muricata Linn) Menggunakan Mukosa Usus Sapi Secara In Vitro
type: item
description: Soursop leaves (Annona muricata Linn) are one of the traditional medicinal plants that have not been extensively studied for their use in cough medicine. Cough is a symptom of respiratory tract disorders and often causes discomfort. One example of a cough is a productive cough. Mucolytics are drugs that work by breaking down mucoprotein strands. This research aims to explore the potential of soursop leaf extract as a mucolytic and identify its active compound groups. The extraction method used is maceration with 70% ethanol. The test uses bovine intestinal mucosa with negative control using phosphate buffer, positive control using herbal medicine X, and the test group using soursop leaf extract with concentrations of 0.5%, 0.75%, and 1%. The viscosity of the test solution is measured with a Rion viscometer. Mucolytic activity is observed through the decrease in mucin viscosity. The research results show that soursop leaf extract at a concentration of 1% has mucolytic effects comparable to herbal medicine X as the positive control. Soursop leaf extract contains compounds such as alkaloids, flavonoids, tannins, and saponins. Keywords: Mucolytic, Soursop Leaf, Bovine Bowels Mucose Abstrak Daun sirsak (Annona muricata Linn) merupakan salah satu tanaman obat tradisional yang belum banyak diteliti penggunaannya sebagai obat batuk. Batuk merupakan gejala adanya gangguan pada saluran pernafasan dan seringkali menyebabkan rasa tidak nyaman. Salah satu contoh batuk yaitu batuk berdahak. Mukolitik merupakan obat yang bekerja dengan cara memecah benang-benang mukoprotein. Penelitian ini bertujuan untuk melihat potensi dari ekstrak daun sirsak sebagai mukolitik dan mengidentifikasi golongan senyawa aktifnya. Metode ekstraksi yang digunakan yaitu maserasi menggunakan etanol 70%. Pengujian ini menggunakan mukosa usus sapi dengan kontrol negatif berupa dapar posfat, kontrol positif berupa obat herbal X dan kelompok uji menggunakan ekstrak daun sirsak dengan konsentrasi 0,5%; 0,75% …
creator: Dea Sefiana Putri
creator: Fika Aryati
creator: Angga Cipta Narsa
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 51
ending page: 56
doi: 10.25026/mpc.v18i1.703

Formulasi Sediaan Sabun Cair Ekstrak Etanol Daun Afrika (Vernonia Amygdalina Delile) dan Aktivitas Antibakterinya
type: item
description: Empirically, African leaves (Vernonia amygdalina delile) have been widely used by Indonesians as medicinal plants, especially for diseases caused by bacteria. Liquid soap is a soap that has a liquid form that produces more foam than solid soap so it is more attractive. This study aims to make the benefits of African leaves can be easily applied, so it is formulated in the form of liquid soap that meets the standards and also has an antibacterial effect. This research uses laboratory experimental qualitative and quantitative methods. The extract was obtained by maceration of simplisia with 96% ethanol, then variating the extract concentration to 5%, 10%, and 20% in the formula. The base formula is variating concentration of VCO, which are 20%, 25%, and 30%. The results showed that base formula 1 (F1) with 5% extract concentration had optimum characteristics, organoleptic test results of dark green color, liquid form that has a distinctive peppermint fragrance, pH value of 10.80, viscosity of 19 dpa.s, density of 1.086 g/mL, water content of 29.5%, foam stability of 95.56%, and free fatty acid content of 0.33%. Antibacterial test results against Staphylococcus aureus and Escerichia coli showed inhibition diameters of 23.8 mm and 25 mm respectively. Keywords: African leaves, Liquid soap, Antibacterial Abstrak Secara empiris daun afrika (Vernonia amygdalina delile) telah banyak digunakan oleh masyarakat Indonesia sebagai tumbuhan obat, salah satunya penyakit yang disebabkan oleh bakteri. Sabun cair merupakan sabun yang memiliki bentuk cairan menghasilkan busa lebih banyak daripada sabun padat sehingga lebih menarik. Penelitian ini, memiliki tujuan untuk membuat kemanfaatan daun afrika tersebut dapat dengan mudah untuk diaplikasikan, sehingga diformulasikan dalam bentuk sabun cair yang memenuhi standar juga memiliki efek antibakteri. Penelitian ini menggunakan metode kualitatif dan kuantitatif eksperimental laboratorium. Ekstrak didapatkan dengan maserasi simplisia denga…
creator: Ervina Irmaya Sagita
creator: Baso Didik Hikmawan
creator: Islamudin Ahmad
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 57
ending page: 65
doi: 10.25026/mpc.v18i1.704

Pengaruh Kemasan Penyimpanan terhadap Kadar Senyawa Non Spesifik Kemangi (Ocimum basilicum L.) pada Suhu Tertentu
type: item
description: Basil (Ocimum basilicum L.) contains the most phenolic compounds among other compounds. This condition contributes to the blackening of basil leaves which can reduce the economic value and quality hence the proper storage packaging is needed. This research was conducted to determine the levels of water soluble and ethanol soluble compounds, post-storage weight changes, and qualitative analysis of phenolic compounds. Basil leaves which have been harvested and sorted then packaged in aluminum foil, banana leaves, polypropylene (PP) plastic and newspaper. The storage process is carried out at a temperature of 5-8ºC for 5 days. After storage is complete, tests are carried out to determine the levels of water-soluble and ethanol-soluble compounds, post-storage weight changes, and qualitative analysis of phenolic compounds. The use of packaging influences changes in post-storage weight of basil where banana leaves have the lowest weight loss of 6%. Meanwhile, qualitative analysis of the compounds in the treatment showed that they still contained phenolic compounds. Keywords: basil, storage packaging, compounds level Abstrak Kemangi (Ocimum basilicum L.) mengandung senyawa fenolik paling banyak di antara senyawa lainnya. Kondisi tersebut berperan kepada penghitaman daun kemangi yang dapat menurunkan nilai ekonomi dan kualitas sehingga dibutuhkan kemasan penyimpanan tepat. Penelitian ini dilakukan untuk mengetahui kadar senyawa larut air dan larut etanol, perubahan bobot pasca simpan, dan analisis kualitatif senyawa fenol. Daun kemangi yang telah dipanen dan disortasi kemudian dikemas ke dalam kemasan alumunium foil, daun pisang, plastik polipropilen (PP), dan kertas koran. Proses penyimpanan dilakukan pada suhu 5-8ºC selama 5 hari. Setelah penyimpanan selesai, dilakukan pengujian untuk mengetahui mengetahui kadar senyawa larut air dan larut etanol, perubahan bobot pasca simpan, dan analisis kualitatif senyawa fenol. Penggunaan kemasan berpengaruh terhadap perubahan bobot p…
creator: Haani Adilah
creator: Riski Sulistiarini
creator: Dewi Rahmawati
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 66
ending page: 71
doi: 10.25026/mpc.v18i1.705

Uji Efek Antidiare Ekstrak Rimpang Kunyit Hitam (Curcuma caesia Roxb.) terhadap Mencit (Mus musculus)
type: item
description: Diarrhea is a disease characterized by increased frequency of defecation and decreased stool consistency caused by impaired absorption of air and electrolytes in the intestine. Black turmeric is a plant that has properties as a traditional medicine for types of diseases, one of which is diarrhea. The aim of this study was to determine the antidiarrheal effect of black turmeric rhizome extract and the best dose of reducing defecation frequency and increasing stool consistency in diarrheal mice. This research was carried out using 40 mice that were induced by diarrhea using Ricini oleum. Mice were divided into 8 groups, the normal group without treatment, the positive control was given Loperamide HCl, the negative control was given 1% NaCMC, the test control group was given 5 variations of doses of black turmeric rhizome extract 50 mg/KgBW, 150 mg/KgBW, 250 mg/KgBW, 300 mg/KgBW, and 500 mg/KgBW. The results showed that black turmeric rhizome extract could reduce the frequency of defecation and increase stool consistency with a significant value (p<0.05). Black turmeric rhizome extract at a dose of 250 mg/KgBW is the best dose because it can reduce the frequency of defecation and increase stool consistency better than Loperamide HCl. Keywords: Antidiarrheal, Black turmeric, Oleum ricini Abstrak Diare merupakan penyakit yang ditandai dengan peningkatan frekuensi defekasi dan penurunan konsistensi feses disebabkan oleh gangguan absorpsi air dan elektrolit di dalam usus. Kunyit hitam disebut sebagai tanaman yang memiliki khasiat sebagai obat tradisional untuk berbagai jenis penyakit salah satunya diare. Tujuan penelitian ini adalah untuk mengetahui efek antidiare ekstrak rimpang kunyit hitam dan dosis terbaik dalam memberikan efek penurunan frekuensi defekasi dan peningkatan konsistensi feses pada mencit diare. Penelitian ini dilakukan dengan menggunakan 40 ekor mencit yang diinduksi diare menggunakan oleum ricini 0,75 ml. Mencit dibagi menjadi 8 kelompok yaitu kelompok n…
creator: Icha Safitri
creator: Riski Sulistiarini
creator: Fahriani Istiqamah Jafar
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 72
ending page: 76
doi: 10.25026/mpc.v18i1.706

Formulasi Sediaan Serum Wajah dari Ekstrak Sarang Burung Walet
type: item
description: The swallow's nest (Edible bird's nest) is included in the Apodidae family. Swallow's nest contains several proteins and amino acids, glutathione and antioxidants. Swallow's nest also contains EGF (Epideral grow factor) which functions to regulate cell growth and development. Facial serum is a preparation with a high concentration of active substances and low viscosity, which can deliver a thin film of active ingredients to the skin surface. The results of this study aim to examine the stability of facial serum formulations from edible bird's nest extract. The results of this research produced facial serum preparations. The results of the physical testing showed that the swallow's nest extract facial serum preparation looked stable without any sediment. Keywords: Edible bird's nest, facial serum, stability test Abstrak Sarang burung walet (Edible bird’s nest) termasuk dalam family Apodidae. Sarang burung walet mengandung beberapa protein dan asam amino, glutathione serta antioksidan. Sarang burung walet juga mengandung EGF (Epideral grow factor)yang berfungsi mengatur pertumbuhan dan perkembangan sel. Serum wajah merupakan sediaan dengan zat aktif konsentrasi tinggi dan viskositas yang rendah, yang dapat menghantarkan film tipis dari bahan aktif pada permukaan kulit. Hasil dari penelitian ini bertujuan untuk melihat stabilitas formulasi sediaan serum wajah dari ekstrak sarang burung walet (Edible bird’s nest). Hasil penelitian ini menghasilkan sediaan serum wajah. Hasil dari pengujian fisik terlihat sediaan serum wajah ekstrak sarang burung walet terlihat stabil tanpa ada endapan. Kata Kunci: Edible bird’s nest, serum wajah, Uji stabilitas
creator: Ina Annisa Rahmadina
creator: Fajar Prasetya
creator: Nur Masyitah Zamruddin
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 77
ending page: 81
doi: 10.25026/mpc.v18i1.707

Efek Beta Sitosterol dan Kunyit Hitam (Curcuma caesia) Terhadap Berat Badan dan Abnormalitas Hati pada Mencit (Mus musculus) yang Diinduksi Etanol
type: item
description: Ethanol can cause fatty liver, hepatitis, and cirrhosis which contribute to liver function’s disorder.Fatty liver is caused by the accumulation of fat in liver cells. Black turmeric (Curcuma caesia) contains curcumin, with hepatoprotective activity and can prevent obesity. Beta-sitosterol is a derivative compound of phytosterol with good hepatoprotective activity Therefore, this study aims to assess the activities of black turmeric and beta-sitosterol as hepatoprotective and anti-obesity agents. Mice were divided into 4 groups: Normal (N), beta-sitosterol 20 mg/kg body weight (BS), black turmeric 6.25% (KH), and negative group (KN). Groups BS, KH, and KN were given 35% ethanol (p.o) for 2 weeks. On the 14th day, body weight were measured and all the mice were dissecter to examine the liver organ. The KH group weight was decreased compared to the normal group. The BS group weight was relatively stable. Macroscopic analysis of the liver organ showed no difference between groups N, BS, and KH. The KN group showed liver swelling as expected. Based on the obtained results, it is assumed that black turmeric prevents weight gain and liver damage due to excessive alcohol-induced. Beta-sitosterol and black turmeric can also prevent the hepatotoxic effects of alcohol consumption Keywords: black turmeric, beta sitosterol, hepatoprotector, anti-obesity Abstrak Etanol dapat merusak fungsi hati seperti perlemakan hati, hepatitis, dan sirosis. Perlemakan pada hati disebabkan oleh penumpukan lemak pada sel hati. Kunyit hitam (Curcuma caesia) memiliki senyawa metabolit sekunder, kurkumin dengan aktivitas hepatoprotektor yang baik dan dapat mencegah terjadinya obesitas. Beta-sitosterol merupakan senyawa turunan pitosterol yang memiliki potensi sebagai hepatoprotektor yang baik. Pada penelitian dilakukan pengujian mengenai aktivitas kunyit hitam dan beta sitosterol sebagai hepatoprotektor dan anti obesitas. Mencit dibagi kedalam 4 kelompok yaitu kelompok Normal (N), kelompok beta sito…
creator: Jihaan Nazhiirah Ilhaam
creator: Putri Anggreini
creator: Hanggara Arifian
creator: Riski Sulistiarini
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 82
ending page: 86
doi: 10.25026/mpc.v18i1.708

Profil Kromatografi Lapis Tipis Antioksidan Tumbuhan Gulma: Axonopus compressus (Sw.) P. Beauv and Digitaria ciliaris (Retz.) Koeler
type: item
description: Weeds are plant species that grow around cultivated crops and are often considered unwanted nuisance plants because they are considered harmful. These weeds, which are often considered a nuisance, can be utilised, especially as a source of medicine. Many studies have presented information on the benefits of weed plants as a source of treatment for degenerative diseases. This study aims to determine the secondary metabolite compounds contained in Axonopus compressus and Digitaria ciliaris weed plants through thin layer chromatographic (KLT) profiles. Extraction was carried out by maceration using methanol solvent and the yield value of Axonopus compressus extract was 3.01% and Digitaria ciliaris extract was 3.27%. The KLT profile test obtained secondary metabolite groups of Axonopus compressus and Digitaria ciliaris methanol extracts, namely flavonoids, alkaloids, steroids/terpenoids, saponins, and tannins. Qualitative test of antioxidant activity using DPPH method on KLT plates of methanol extracts of Axonopus compressus and Digitaria ciliaris obtained positive results of yellow stains with RF values of 0.6; 0.65 and 0.7 which indicate the presence of compounds that have antioxidant activity. Keywords: Axonopus compressus, Digitaria ciliaris, thin layer chromatography, antioxidant Abstrak Gulma merupakan spesies tumbuhan yang tumbuh disekitar tanaman budidaya dan sering dianggap sebagai tumbuhan pengganggu yang tidak diinginkan karena dianggap merugikan. Tumbuhan gulma yang sering dianggap mengganggu ini dapat dimanfaatkan khususnya sebagai sumber pengobatan. Telah banyak Penelitian yang menyajikan informasi mengenai manfaat tumbuhan gulma sebagai sumber pengobatan penyakit degeneratif. Penelitian ini bertujuan untuk mengetahui senyawa metabolit sekunder yang terkandung pada tumbuhan gulma Axonopus compressus and Digitaria ciliaris melalui profil kromatografi lapis tipis (KLT). Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut metanol dan didapatkan hasil…
creator: Mersi Mersi
creator: Venna Sinthary
creator: Laode Rijai
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 87
ending page: 91
doi: 10.25026/mpc.v18i1.709

Penentuan Nilai Sun Protection Factor (SPF) Ekstrak Etanol Rimpang Kunyit Hitam (Curcuma caesia ROXB.) dengan Metode Spektrofotometri UV-Vis
type: item
description: Black turmeric (Curcuma caesia ROXB.) is a species of turmeric, the Zingberaceae family which has high antioxidant activity and is closely related to sunscreen activity, which is a compound that absorbs or reflects sunlight so that it can prevent skin disorders. This research aims to determine the Sun Protection Factor (SPF) value of ethanol extract of black turmeric rhizomes using the soxletation extraction method using 96% ethanol solvent and determining the SPF value using the UV-Vis spectrophotometric method. Tests were carried out using varying extract concentrations of 100 ppm, 150 ppm, 200 ppm, 250 ppm and 300 ppm measured at a UV wavelength of 290-320 nm. The research results showed that the SPF values ??of the 100 ppm, 150 ppm, 200 ppm, 250 ppm and 300 ppm concentration series were 10,93; 10,90; 13,49; 19,31; 20,42. Based on these results, it was concluded that the high SPF values ??were found at concentrations of 250 ppm and 300 ppm, namely 19,31 and 20,42 which were included in the ultra protection category. Keywords: Black Turmeric, SPF, UV-Vis Spectrophotometry Abstrak Kunyit hitam (Curcuma caesia ROXB.) merupakan salah satu spesies dari kunyit, dari family Zingberaceae yang memiliki aktivitas antioksidan yang tinggi dan memiliki hubungan erat dengan aktivitas tabir surya yang merupakan senyawa untuk menyerap atau memantulkan sinar matahari sehingga dapat mencegah gangguan pada kulit. Penelitian ini bertujuan untuk mengetahui nilai Sun Protection Factor (SPF) ekstrak etanol rimpang kunyit hitam dengan metode ekstraksi soxletasi menggunakan pelarut etanol 96% dan penentuan nilai SPF menggunakan metode spektrofotometri UV-Vis. Pengujian dilakukan dengan menggunakan variasi konsentrasi ekstrak sebesar 100 ppm, 150 ppm, 200 ppm, 250 ppm dan 300 ppm yang diukur pada panjang gelombang UV 290-320 nm. Hasil penelitian menunjukkan bahwa nilai SPF dari seri konsentrasi 100 ppm, 150 ppm, 200 ppm, 250 ppm dan 300 ppm berturut-turut 10,93; 10,90; 13,49; 19,31; 20,42…
creator: Miranda Ibau
creator: Riski Sulistiarini
creator: Supriatno Salam
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 92
ending page: 96
doi: 10.25026/mpc.v18i1.710

Karakteristik Ekstrak Daun Kersen (Muntingia calabura L.) sebagai Kandidat Bahan Aktif dalam Formulasi Gel Sleeping Mask
type: item
description: Kersen plant (Muntingia calabura L.) is one of the plants that has antioxidant activity. The phytochemical content in kersen plants includes flavonoids, terpenoids, steroids, phenolics, saponins and tannins. This content makes kersen plants have high antioxidant activity and potential to be formulated in the form of sleeping mask gel. Antioxidants have an important role that can neutralize free radicals in the body, where these free radicals are closely related to accelerated aging and carcinogenic. Therefore, the antioxidant activity of kersen leaf extract was tested quantitatively using a UV-Vis spectrophotometer to determine the potential of kersen plants as a source of antioxidants. The results showed that kersen plant has characteristics of blackish brown color, solid form, distinctive aroma, with an extract pH of 4.29. The content of secondary metabolite compounds in it include flavonoids, alkaloids, and tannins. The results of the antioxidant activity test of kersen leaf extract showed an IC50 value of 13.11242 and was included in the very strong category. Keywords: Kersen Leaf, Extract, Antioxidant Abstrak Tumbuhan kersen (Muntingia calabura L.) merupakan salah satu tumbuhan yang memiliki aktivitas antioksidan. Kandungan fitokimia dalam tanaman kersen meliputi flavonoid, terpenoid, steroid, fenolik, saponin dan tanin. Kandungan ini menjadikan tumbuhan kersen memiliki aktivitas antioksidan yang tinggi dan berpotensi untuk diformulasikan dalam bentuk sediaan gel sleeping mask. Antioksidan memiliki peran penting yaitu dapat menetralkan radikal bebas yang ada di dalam tubuh, dimana radikal bebas ini berkaitan erat dengan percepatan penuaan dan karsinogenik. Oleh karena itu, dilakukan pengujian aktivitas antioksidan ekstrak daun kersen secara kuantitatif menggunakan spektrofotometer UV-Vis untuk mengetahui potensi tumbuhan kersen sebagai sumber antioksidan. Hasil penelitian menunjukkan bahwa tumbuhan kersen memiliki karakteristik warna coklat kehitaman, berwujud …
creator: Mirda Fitria Islamika
creator: Nurus Sobah
creator: Angga Cipta Narsa
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 97
ending page: 102
doi: 10.25026/mpc.v18i1.711

Skrining Fitokimia dan Karakterisasi Minyak Biji Kemiri (Aleurites moluccana L.)
type: item
description: Candlenut is an intriguing plant, especially for its activities as a hair strengthener and its antibacterial properties. Various techniques can be employed to obtain candlenut oil, one of which is the roasting method. This method is cost-effective and easy to perform. However, there is currently no information on the phytochemical composition of candlenut oil produced using the roasting method. The aim of this research is to identify the groups of chemical compounds present in candlenut oil and to characterize candlenut oil. The research methodology for screening the phytochemicals in candlenut oil includes testing for alkaloids, flavonoids, steroids/terpenoids, tannins, phenols, and saponins. Characterization of candlenut oil includes organoleptic tests, water content analysis, acid value determination, saponification value determination, and density testing. The phytochemical screening results indicate that candlenut oil contains alkaloids, flavonoids, and steroids. The characterization results for candlenut oil reveal that it has a yellow color, smooth texture, and a distinctive candlenut oil scent. The water content is 0.01%, the acid value is 5%, the saponification value is 184.1825 mg KOH/g, and the density is 1.03 g/mL. This result shows that the obtained candlenut oil meets the Indonesian National Standard (SNI) for oil. Keywords: Candlenut, Phytochemical screening, Characterization Abstrak Kemiri merupakan tanaman yang menarik, khususnya aktivitasnya sebagai penguat rambut serta aktivitas antibakterinya. Berbagai teknik dapat dilakukan untuk mendapatkan minyak biji kemiri, salah satunya dengan metode sangrai. Metode ini merupakan metode yang murah dan mudah dilakukan. Namun belum ada informasi fitokimia terhadap minyak kemiri yang dihasilkan dengan metode sangrai. Tujuan dari penelitian ini untuk mengetahui golongan senyawa kimia yang terkandung pada minyak biji kemiri dan mengkarakterisasi minyak biji kemiri. Metode penelitian skrining fitokimia minyak bij…
creator: Muhammad Azril Rizqullah
creator: Abdul Rahim
creator: Lizma Febrina
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 103
ending page: 108
doi: 10.25026/mpc.v18i1.712

Validasi Metode dan Penetapan Kadar Kafein Menggunakan Spektrofotometri UV-Vis
type: item
description: Caffeine is one of the alkaloids contained in coffee. Caffeine in coffee has clinically useful pharmacological effects, such as stimulating the central nervous system, relieving fatigue and drowsiness. This study aims to determine the validation of the analytical method for determining caffeine content in robusta coffee, where the sample used is coffee from Kalimantan and Sulawesi. The analytical method used to determine caffeine levels in coffee is UV-Vis spectrophotometry. Parameters in method validation are linearity, LOD and LOQ, precision, and accuracy. The validation test performed showed linear results where the value of r2 was 0,9927. The limit value of detection (LOD) obtained is 25,9344 and the value limit quantity (LOQ) obtained is 78,5893. The results of the accuracy test are expressed in %recovery, which is 106,7%. In the final stage a precision test was carried out where the RSD value obtained was 1,5937%. In determining the caffeine content, the caffeine content for Sulawesi coffee was 0,466 mg/g and for Kalimantan coffee was 0,591 mg/g. Keywords: Caffeine, Spektrophotometry UV-Vis, Method validation Abstrak Kafein merupakan salah satu alkaloid yang terkandung dalam kopi. Kafein pada kopi memiliki efek farmakologis yang bermanfaat secara klinis, seperti merangsang sistem saraf pusat, menghilangkan rasa lelah dan mengantuk. Penelitian ini bertujuan untuk mengetahui validasi metode analisis pada penetapan kadar kafein dalam kopi robusta, dimana sampel yang digunakan adalah kopi yang berasal dari Kalimantan dan Sulawesi. Metode analisis yang digunakan untuk menetapkan kadar kafein dalam kopi adalah spektrofotometri UV-Vis. Parameter pada validasi metode yaitu linearitas, LOD dan LOQ, presisi, dan akurasi. Pengujian validasi yang dilakukan menunjukkan hasil yang linier dimana nilai r2 adalah 0,9927. Nilai limit deteksi (LOD) yang diperoleh adalah 25,9344 dan nilai limit kuantitas (LOQ) yang diperoleh adalah 78,5893. Hasil uji akurasi dinyatakan dalam %rec…
creator: Nia Fevniaty Rupa
creator: Sabaniah Indjar Gama
creator: Islamudin Ahmad
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 109
ending page: 115
doi: 10.25026/mpc.v18i1.713

Optimasi Pembuatan Nanopartikel Ekstrak Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) Berdasarkan Konsentrasi Kitosan
type: item
description: Dayak onion extract (Eleutherine bulbosa (Mill.) Urb.) is known to have strong antibacterial activity so it has the potential to be developed into a nanoparticle delivery system. Chitosan polymer has the advantage of delivering active substances because it has good stability, low toxicity, and the preparation method is quite simple. This research aims to determine the effect of variations in chitosan–tripolyphosphate (TPP) concentration on the size and polydispersity index of nanoparticles. Dayak onion extract was formulated in the form of nanoparticles using the ionic gelation method with varying concentrations of chitosan polymer: tripolyphosphate 0.1%, 0.2%, 0.3% and 0.4%. Test parameters include determining the size and polydispersity index of nanoparticles using a particle size analyzer. The results showed that F1, F2, F3, and F4 had particle sizes of 376.6 nm, 354.7 nm, 480.1 nm, 654.0 nm, respectively, and a polydispersity index of 1.666; 1,702; 0.949; and 1,585 with heterogeneous size distribution. Based on the results of research that has been carried out, it can be concluded that Dayak onion extract can be formulated in nanoparticle sizes with varying physical characteristics depending on the concentration of chitosan and tripolyphosphate used. Keywords: Dayak onion (Eleutherine bulbosa (Mill.) Urb.), nanoparticles, chitosan, tripolyphosphate, ionic gelation Abstrak Ekstrak bawang dayak (Eleutherine bulbosa (Mill.) Urb.) diketahui memiliki aktivitas antibakteri yang kuat sehingga berpotensi untuk dikembangkan menjadi sistem penghantaran nanopartikel. Polimer kitosan memiliki kelebihan untuk menghantarkan zat aktif karena memiliki stabilitas yang baik, toksisitas yang rendah, dan metode preparasinya yang cukup sederhana. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi kitosan–tripolifosfat (TPP) terhadap ukuran dan indeks polidisperitas nanopartikel. Ekstrak bawang dayak diformulasi dalam bentuk nanopartikel dengan metode gelasi ionik…
creator: Nintra Mahdan Liranti
creator: Muhammad Burhanudin
creator: Yurika Sastyarina
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 116
ending page: 119
doi: 10.25026/mpc.v18i1.714

Skrining Fitokimia dan Pengujian Toksisitas Ekstrak Etanol Buah Mangrove (Sonneratia ovata) dengan Metode Brine Shrimp Lethality Test (BSLT)
type: item
description: The mangrove plant (Sonneratia ovata) serves ecological, culinary, and traditional medicinal purposes, such as treating asthma, reducing fever, addressing hemorrhoids, muscle pain, back pain, bone pain, joint pain, and hepatitis. However, data on the toxicity of this plant is still limited. This research aims to determine the yield value, secondary metabolite outcomes, and toxicity profile of ethanol extract from mangrove fruits (Sonneratia ovata). The research method involves sample preparation, maceration extraction with 96% ethanol, phytochemical screening, and toxicity testing using the BSLT method. The findings reveal a yield value of 56.458% for the mangrove fruit extract. Phytochemical screening indicates the presence of flavonoids, tannins, phenolics, and saponins in the ethanol extract. The toxicity test results show a toxicity value of 7727.914 ppm for the mangrove fruit ethanol extract. In conclusion, based on the BSLT method, the ethanol extract of mangrove fruit falls into the non-toxic category. Keywords: Sonneratia ovata, Maceration, Phytochemical Test, BSLT Abstrak Tanaman mangrove (Sonneratia ovata) memiliki manfaat sebagai ekologi, bahan pangan dan juga sebagai bahan tradisional dalam pengobatan asma, menurunkan panas, pengobatan ambeien, nyeri otot, sakit pinggang, sakit tulang, sakit persendian dan hepatitis namun data toksisitas mengenai tanaman ini masih kurang. Tujuan penelitian ini adalah untuk mengetahui nilai rendemen, hasil dari metabolit sekunder serta profil toksisitas ekstrak etanol buah mangrove (Sonneratia ovata). Metode penelitian ini yaitu diawali dengan preparasi sampel lalu ekstraksi maserasi dengan etanol 96%, dilanjutkan dengan uji skrining fitokimia serta uji toksisitas dengan metode BSLT. Hasil yang diperoleh dari penelitian ini adalah nilai rendemen dari ekstrak buah mangrove yaitu sebesar 56,458%. Hasil skrining fitokimia menunjukkan ekstrak etanol buah mangrove positif mengandung flavonoid, tannin, fenolik dan saponin. Hasi…
creator: Noor Fitriani
creator: Muhammad Faisal
creator: Risna Agustina
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 120
ending page: 126
doi: 10.25026/mpc.v18i1.715

Kajian Metabolit Sekunder dan Potensi Antibakteri Daun Banitan (Monocarpia kalimantanensis)
type: item
description: The Banitan plant (Monocarpia kalimantanensis) is a plant in the Annonaceae family that can be found in Samboja, East Kalimantan. The aim of this research is to identify and determine the content of secondary metabolite compounds and antibacterial activity contained in banitan leaves. The method used for antibacterial testing was well diffusion and the positive control used was Amoxicillin. The results obtained from this research were a yield with a value of 12.35%, then in secondary metabolites there were alkaloids, triterpenoids, flavonoids, phenolics, saponins and tannins. Antibacterial testing using well diffusion obtained the best results against Escherichia coli at a concentration of 15%. And for Staphylococcus aureus bacteria, the best concentration was found at 25%. Keywords: Banitan (Monocarpia kalimantanensis), phytochemicals, yield, antibacterial, well diffusion Abstrak Tanaman Banitan (Monocarpia kalimantanensis) merupakan tanaman berfamili Annonaceae yang dapat dijumpai di Samboja, Kalimantan Timur. Tujuan dari penelitian ini adalah mengidentifikasi dan mengetahui kandungan senyawa metabolit sekunder, dan Aktivitas antibakteri yang terdapat dalam daun banitan. Metode yang dilakukan pada pengujian antibakteri adalah difusi sumuran dan kontrol positif yang digunakan adalah Amoxicillin. Hasil dari penelitian ini yang didapat adalah hasil rendemen dengan nilai 12,35%, kemudian pada metabolit sekunder terdapat senyawa alkaloid, triterpenoid, flavonoid, fenolik, saponin, dan tannin. Pengujian antibakteri dengan difusi sumuran didapat hasil terbaik terhadap Escherichia coli pada konsentrasi 15%. Dan pada bakteri Staphylococcus aureus didapat konsentrasi terbaik pada 25%. Kata Kunci: Banitan (Monocarpia kalimantananensis), Fitokimia, Rendemen, Antibakteri, Difusi Sumuran
creator: Nugra Ilmahdi
creator: Fahriani Istiqamah Jafar
creator: Laode Rijai
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 127
ending page: 135
doi: 10.25026/mpc.v18i1.716

Karakteristik Teh Herbal Daun Kersen (Muntingia calabura L.) dan Daun Salam (Syzygium polyanthum) Sebagai Antioksidan
type: item
description: Antioxidants can protect body cells from damage caused by free radicals. Free radicals can damage cells and body tissue. The body has natural antioxidants but not in large quantities so the body needs antioxidants that come from outside. Antioxidants from outside the body can come from various natural ingredients native to Indonesia which have potential as antioxidants, one of which comes from cherry leaves (Muntingia calabura L.) and bay leaves (Syzygium polyanthum). This research aims to determine the antioxidant activity of cherry leaf (Muntingia calabura L.) and bay leaf (Syzygium polyanthum) herbal tea so that people can use it as an alternative source of antioxidants. The data collection method is carried out using instruments in the laboratory. The research results showed that cherry leaves (Muntingia calabura L.) and bay leaves (Syzygium polyanthum) were identified as containing alkaloids, flavonoids, saponins, tannins and terpenoids. Simplicia's characteristic data meets the requirements of SNI (Indonesian National Standards). As well as the IC50 value of herbal tea, cherry leaves (Muntingia calabura L.) were found to be 1,39 µg/ml and bay leaves (Syzygium polyanthum) 1,72 µg/ml, which means they have very strong antioxidant activity because the IC50 value is <50. Keywords: Characteristics, Herbal tea of ??cherry leaves (Muntingia calabura L.) and bay leaves (Syzygium polyanthum), Antioxidants, IC50 value Abstrak Antioksidan dapat melindungi sel tubuh dari kerusakan yang disebabkan radikal bebas. Radikal bebas dapat merusak sel serta jaringan tubuh. Tubuh memiliki antioksidan alami tetapi tidak dalam jumlah besar sehingga tubuh membutuhkan antioksidan yang berasal dari luar. Antioksidan dari luar tubuh dapat berasal dari berbagai macam bahan alam asli Indonesia yang memiliki potensi sebagai antioksidan, salah satunya berasal dari daun kersen (Muntingia calabura L.) dan daun salam (Syzygium polyanthum). Penelitian ini bertujuan untuk menentukan aktivitas ant…
creator: Nurfitri Nurfitri
creator: Herman Herman
creator: Maryam Jamila Arief
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 136
ending page: 142
doi: 10.25026/mpc.v18i1.717

Pengaruh Beberapa Variasi Konsentrasi Kitosan Terhadap Potensial Zeta Nanopartikel Ekstrak Bawang Dayak (Eleutherine bulbosa)
type: item
description: Dayak onion bulb extract (Eleutherine bulbosa) contains alkaloids, flavonoids and saponin which have antioxidant and antidiabetic activity. The bioavailability of dayak onion bulb extract can theoretically be increased by reducing the particle size of the extract into nanoparticles. The zeta potential value is one of the factors that influences the surface charge and stability of nanoparticles. This research aims to determine the effect of several variations in chitosan concentration on the zeta potential of dayak onion extract nanoparticles. Dayak onion extract nanoparticle formulation was carried out with 4 variations of chitosan concentration, namely 0,1%, 0,2%, 0,3%, and 0,4%. The results of the zeta potential value for each chitosan concentration are -20,8 mV, 11,2 mV, 23,7 mV, and 29,5 mV. Keywords: extract, dayak onion, nanoparticles, zeta potential Abstrak Ekstrak umbi bawang dayak (Eleutherine bulbosa) mengandung alkaloid, flavonoid, dan saponin yang memiliki aktivitas sebagai antioksidan dan antidiabetes. Bioavailabilitas ekstrak umbi bawang dayak secara teori dapat ditingkatkan dengan memperkecil ukuran partikel ekstrak menjadi nanopartikel. Nilai potensial zeta adalah salah satu faktor yang mempengaruhi muatan permukaan dan stabilitas nanopartikel. Penelitian ini bertujuan untuk mengetahui pengaruh beberapa variasi konsentrasi kitosan terhadap potensial zeta nanopartikel ekstrak bawang dayak. Formulasi nanopartikel ekstrak bawang Dayak dilakukan dengan 4 variasi konsentrasi kitosan, yaitu 0,1%, 0,2%, 0,3%, dan 0,4%. Hasil nilai potensial zeta masing-masing konsentrasi kitosan berturut-turut adalah -20,8 mV, 11,2 mV, 23,7 mV, dan 29,5 mV. Kata Kunci: ekstrak, bawang dayak, nanopartikel, potensial zeta
creator: Nurul Fadhilah
creator: Mentarry Bafadal
creator: Yurika Sastyarina
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 144
ending page: 148
doi: 10.25026/mpc.v18i1.718

Isolasi dan Karakterisasi Jamur Endofit Daun Belimbing Hutan (Cnestis palala (Lour.) Merr)
type: item
description: Belimbing hutan (Cnestis palala (Lour.) Merr) is recognized as a distinctive plant in East Kalimantan, commonly used by the local community for treating internal diseases, postpartum conditions, abdominal pain, and urinary tract disorders. The benefits of belimbing hutan cannot be separated from the compounds contained in it. However, the limited population makes exploration of this plant hampered. Endophytic fungi are an interesting alternative for exploring secondary metabolites from this plant. To date, there have been no scientific reports on endophytic fungus of belimbing hutan. This research successfully isolated and characterized three isolates from the leaves of belimbing hutan with isolate codes IJP1 exhibiting white colonies with a cotton-like texture, IJP2 colonies are white and fiber-shaped, IJH1 with green colonies accompanied by concentric circles. The diversity of endophytic fungi in belimbing hutan leaves opens up possibilities for discovering potential compounds from the extracts of these fungi. Keywords: Cnestis palala (Lour.) Merr, Endophytic Fungi, Isolation, Characterization Abstrak Belimbing hutan (Cnestis palala (Lour.) Merr) dikenal sebagai tanaman khas Kalimantan Timur yang umumnya digunakan sebagai obat penyakit dalam, obat pasca melahirkan, sakit perut dan gangguan saluran kemih oleh masyarakat sekitar. Khasiat dari belimbing hutan ini tidak terlepas dari senyawa yang terkandung di dalamnya. Namun, populasi yang terbatas membuat eksplorasi tumbuhan ini menjadi terhambat. Jamur endofitik merupakan salah satu alternatif menarik untuk mengeksplorasi metabolit sekunder dari tanaman ini. Sepanjang pengetahuan, belum ada laporan ilmiah mengenai jamur endofitik belimbing hutan. Penelitian ini berhasil mengisolasi dan mengkarakterisasi tiga isolat dari daun belimbing hutan dengan kode isolat IJP1 yang memiliki karakteristik koloni berwarna putih dan tekstur halus seperti kapas, IJP2 koloni berwarna putih dan berbentuk serabut, IJH1 koloni berwarna…
creator: Nurvidya Sistha Azzahra
creator: Nisa Naspiah
creator: Lizma Febrina
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 149
ending page: 154
doi: 10.25026/mpc.v18i1.719

Aktivitas Antimikroba Ekstrak dan Fraksi Kulit Batang Banitan (Monocarpia kalimantanensis)
type: item
description: Banitan (Monocarpia kalimantanensis) is a plant that grows in the Samboja area, East Kalimantan. Antimicrobial activity extract and fractions of banitan stem barks against Staphylococcus aureus, Escherichia coli, and Candida albicans has never been done. This study aims to determine the yield and antimicrobial activity produced by banitan bark extract and fractions (n-hexane, ethyl acetate and n-butanol) against Staphylococcus aureus, Escherichia coli, and Candida albicans. Antimicrobial activity was assayed by agar well diffusion method using 5 concentration groups of the extract and fractions of banitan stem bark, namely 0,625%; 1,25%; 2,5%; 5%; and 10% with chloramphenicol and ketoconazole as positive control and DMSO 10% as negative control. The diameter inhibition zone value of ethanol extract, n-hexane, ethyl acetate and n-butanol fractions at the concentration 10% for Staphylococcus aureus were 13,63; 9,08; 21,18; 6,05 mm, Escherichia coli were 14,46; 9,93; 21,97; 6,90 mm and Candida albicans were 11,85; 18,09; 19,36; 13,17 mm. The ethyl acetate fraction showed the highest inhibitory activity at a concentration of 10%. Keywords: Monocarpia kalimantanensis, antimicrobial Abstrak Banitan (Monocarpia kalimantanensis) adalah tanaman yang tumbuh di daerah Samboja, Kalimantan Timur. Aktivitas antimikroba ekstrak dan fraksi kulit batang banitan terhadap Staphylococcus aureus, Escherichia coli, dan Candida albicans belum pernah dilakukan. Penelitian ini bertujuan untuk mengetahui aktivitas antimikroba yang dihasilkan oleh ekstrak dan fraksi (n-heksana, etil asetat dan n-butanol) dari kulit batang banitan terhadap Staphylococcus aureus, Escherichia coli, dan Candida albicans. Aktivitas antimikroba diuji dengan metode difusi agar kertas cakram menggunakan 5 kelompok konsentrasi yaitu 0,625%; 1,25%; 2,5%; 5%; dan 10% dengan kloramfenikol dan ketokonazol sebagai kontrol positif dan DMSO 10% sebagai kontrol negatif. Ekstrak etanol, fraksi n-heksana, etil asetat dan n-buta…
creator: Otsuka Khaera Nurmala
creator: Fahriani Istiqamah Jafar
creator: Herman Herman
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 155
ending page: 161
doi: 10.25026/mpc.v18i1.720

Identifikasi Potentially Inappropriate Medication (PIM’s) Menggunakan Kriteria Beers dan STOPP pada Pasien Geriatri dengan Diagnosis Gastrointestinal Rawat Inap di RSUD Abdul Wahab Sjahranie Samarinda
type: item
description: The Beers and STOPP criteria are criteria used to identify possible inappropriate treatment including drugs that should be avoided and used in patients older than 65 years. These two criteria are a reference in evaluating the prescription of potentially inappropriate medications or Potentially Inappropriate Medications (PIM's) in geriatrics. The aim of the research is to determine geriatric characteristics, treatment profiles in prescribing and PIM's based on the Beers criteria and STOPP criteria in geriatric patients with gastrointestinal diagnoses who are hospitalized at Abdul Wahab Sjahranie Hospital, Samarinda. This research used an observational research design with data collected retrospectively and analyzed descriptively. The research results obtained from 80 patient data showed that geriatric patients were predominantly female as many as 47 patients (59%) with young elderly aged 65 - 74 years as many as 53 patients (66.25%) with the most dominant diagnosis being diarrhea and dyspepsia as many as 36 patients (42.85%) and the most common comorbidity was hypertension in 17 patients (30.35%). The most dominant use of medication in geriatric patients was antiemetic therapy, 64 patients (80%). Based on PIM's analysis using the Beers and STOPP criteria, no events were found according to the Beers criteria and of the 23 cases included in drug use, only 1 incident was found using the STOPP criteria. Keywords: Beers, Geriatric, STOPP, Potentially inappropriate medication (PIM’s) Abstrak Kriteria Beers dan STOPP adalah kriteria yang digunakan untuk mengidentifikasi kemungkinan pengobatan yang tidak tepat termasuk obat yang harus dihindari dan digunakan pada pasien yang berusia lebih dari 65 tahun. Kedua kriteria ini menjadi acuan dalam mengevaluasi peresepan obat yang berpotensi tidak tepat penggunaannya atau Potentially Inappropriate Medication (PIM’s) pada geriatri. Tujuan penelitian yaitu mengetahui karakteristik geriatri, profil pengobatan pada peresepan serta PIM’…
creator: Rahmayunitha Muriana
creator: Maria Almeida
creator: Adam M. Ramadhan
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 162
ending page: 170
doi: 10.25026/mpc.v18i1.721

Evaluasi Penggunaan Obat pada Pasien Artritis Gout di Instalasi Rawat Jalan Rumah Sakit Pupuk Kaltim Bontang Periode 2022
type: item
description: Arthritis gout is a disease due to deposition of monosodium urate (MSU) crystals in the joints, kidneys, and other connective tissues as a result of hyperuricemia which can cause pain, swelling, impaired joint movement, and even tophi. Without rational treatment, there will be overdiagnosis and inadequate management which can aggravate gout. This study used observational studies and descriptive methods in 87 samples at the outpatient installation of Pupuk Kaltim Hospital Bontang Period 2022. The results of the study of patient characteristics based on age were most in the age group 46-55 years with a total of 25 patients (28.7%), based on gender more occurred in men with a total of 75 male patients (86.2%), based on the most symptoms were pain with a total of 69 cases (68.3%), and based on the highest diagnosis was acute gouty arthritis with a total of 76 patients (87.3%). The results showed that the most widely used antipyretic therapy was Allopurinol, which was used by 62 patients, followed by Colchicine which was used by 47 patients. For analgesic, antipyretic, and anti-inflammatory therapy, NSAIDs were used by 23 patients and Paracetamol was used by 6 patients. Keywords: gout arthritis, characteristics, treatment pattern Abstrak Artritis gout adalah penyakit akibat deposisi kristal monosodium urat (MSU) di sendi, ginjal, dan jaringan ikat lainnya sebagai akibat dari hiperurisemia yang dapat menimbulkan nyeri, bengkak, gangguan gerak sendi, dan bahkan tophi. Tanpa pengobatan yang rasional, akan terjadi overdiagnosis dan tata laksana yang tidak adekuat yang dapat memperparah gout. Penelitian ini menggunakan studi observasional dan dengan metode deskriptif pada 87 sampel di instalasi rawat jalan Rumah Sakit Pupuk Kaltim Bontang Periode 2022. Hasil penelitian karakteristik pasien berdasarkan usia terbanyak pada kelompok usia 46-55 tahun dengan jumlah 25 pasien (28,7%), berdasarkan jenis kelamin lebih banyak terjadi pada laki-laki dengan jumlah sebanyak 75 pasien lak…
creator: Silvia Ningsih Manurung
creator: Hadi Kuncoro
creator: Junaidin Junaidin
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 171
ending page: 176
doi: 10.25026/mpc.v18i1.722

Observasi Klinik Penggunaan Obat Sariawan pada Remaja
type: item
description: Thrush is a disease of the oral mucosa that is often experienced by the public. There are various options in curing thrush such as using synthetic drugs containing antiseptics or analgesics. In healing canker sores itself can also use other alternatives such as the use of natural materials that have a function as analgesics. This study aims to determine the types of canker sore treatments used by adolescents today and the effectiveness of these treatments. The method of this study is observational with the number of respondents to date is 70 respondents selected based on inclusion criteria. The results showed that there were 22 respondents who used drugs containing vitamin c. In addition there were also Triamsinolon acetonide 1 mg, Povidone Iodine, phenol crystal 14%, Policrusulen, Borax Glycerine gom 10%, Nystatin, Dequalinium chloride, with alternative treatments such as, drugs containing Glycyrrhizae Glabra Radix and Sophorae Tonkinesis Radix, Betel Black, Salt, Honey, Tomatoes, Aloe Vera Extract, Tamarind. The effectiveness of treatment is seen from the duration of treatment where the average duration of the entire treatment is 6-7 days. It was concluded that the most common treatment used by respondents was treatment containing vitamin c either in the form of drinks or in the form of chips, while the most effective treatment in terms of the duration of canker sores was the alter treatment. Keywords: Medicine, Thrush, Recurrent Aphthous Stomatitis, Effectiveness Abstrak Sariawan merupakan penyakit pada mukosa mulut yang sering dialami oleh masyarakat. Terdapat berbagai pilihan dalam menyembuhkan sariawan seperti menggunakan obat sintetik yang mengandung antiseptik ataupun analgesik. Pada penyembuhan sariawan ini sendiri dapat juga menggunakan alternatif lain seperti penggunaan bahan alam yang memiliki fungsi sebagai analgesik. Penelitian ini bertujuan untuk mengetahui macam-macam pengobatan sariawan yang digunakan remaja saat ini serta efektivitas dari pengobata…
creator: Sitti Mujahida Tahir
creator: Niken Indriyanti
creator: Siti Rouchmana
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 177
ending page: 181
doi: 10.25026/mpc.v18i1.723

Uji Aktivitas Antioksidan Berdasarkan Perbedaan Tingkat Kematangan Buah Alpukat (Persea americana Mill.) Menggunakan Metode DPPH
type: item
description: Avocado fruit (Persea americana Mill.) has activity as an antioxidant. This activity is strongly influenced by the metabolites contained in avocados. However, the formation of these active metabolites is greatly influenced by the level of fruit ripening. To the best of our knowledge there have been no scientific reports regarding the antioxidant activity of avocados with different levels of ripeness. So researchers want to know antioxidant activity based on differences in avocado ripeness levels. The avocados observed were unripe, tree-ripened and ripe avocados. Determination of antioxidant activity was carried out using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with a UV-Vis spectrophotometer at a wavelength of 516 nm. The antioxidant activity results obtained were in the form of an IC50 (inhibition concentration) value for raw avocados of 39.83 ppm, tree ripe avocados of 30.29 ppm, and peram ripe avocados of 28.60 ppm. All three are classified as very strong antioxidants, with the best antioxidant activity in ripe avocados. This shows that differences in fruit ripeness levels affect their antioxidant activity. Keywords: Avocado, Antioxidant, DPPH Abstrak Buah alpukat (Persea americana Mill.) memiliki aktivitas sebagai antioksidan. Aktivitas ini sangat dipengaruhi oleh metabolit yang terkandung pada buah alpukat. Namun demikian pembentukan metabolit-metabolit aktif ini sangat dipengaruhi oleh tingkat pematangan buah. Sepanjang pengetahuan kami belum ada laporan ilmiah mengenai aktivitas antioksidan buah alpukat dengan tingkat kematangan yang berbeda. Sehingga peneliti ingin mengetahui aktivitas antioksidan berdasarkan perbedaan tingkat kematangan buah alpukat. Buah alpukat yang diamati adalah buah alpukat mentah, matang pohon, dan matang peram. Penentuan aktivitas antioksidan dilakukan dengan menggunakan metode DPPH (2,2-diphenyl-1-picrylhydrazyl) dengan spektrofotometer UV-Vis pada panjang gelombang 516 nm. Hasil aktivitas antioksidan yang diperoleh berupa n…
creator: Tri Ratnasari
creator: Abdul Rahim
creator: Lizma Febrina
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 182
ending page: 186
doi: 10.25026/mpc.v18i1.724

Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Daun Cabai Rawit (Capsiccum frutescens L.) terhadap Staphylococcus epidermidis
type: item
description: Cayenne pepper leaves (Capsiccum frutescens L.) are a plant that has many benefits, one of which is in the health sector. Scientifically, cayenne pepper leaves act as an antioxidant, antibacterial and can prevent diabetes. This activity is caused by the chemical compounds contained in the plant. This research aims to determine the antibacterial activity of cayenne pepper leaf extract. The extraction process was carried out using 70% ethanol solvent using the maceration method. From the extraction results, 221.5 grams of thick extract was obtained so that the yield value was 31.57%. The results of the phytochemical screening test on the 96% ethanol extract of cayenne pepper leaves (Capsiccum frutescens L.) showed that the 96% ethanol extract of cayenne pepper leaves contained alkaloids, saponins, tannins, terpenoids and flavonoids. The results showed that cayenne pepper leaf extract has antibacterial activity against Staphylococcus epidermidis bacteria with inhibitory extract power at concentrations of 5%, namely 1.82 mm, 10%, namely 3.42 mm, and 15%, namely 6.04 mm. Keywords: Cayenne pepper leaves (Capsiccum frutescens L.), phytochemicals, yield value, antibacterial Abstrak Daun cabai rawit (Capsiccum frutescens L.) merupakan tanaman yang memiliki banyak manfaat salah satunya di bidang kesehatan. Secara ilmiah daun cabai rawit berperan sebagai antioksidan, antibakteri dan dapat mencegah diabetes. Aktivitas tersebut disebabkan oleh kandungan senyawa kimia yang terdapat di dalam tanaman tersebut. Penelitian ini bertujuan untuk menetahui aktivitas antibakteri ekstrak daun cabai rawit. Proses ekstraksi dilakukan menggunakan pelarut etanol 70% dengan metode maserasi. Dari hasil ekstrasi didapatkan ekstrak kental sebanyak 221,5 gram sehingga nilai rendemen diperoleh 31,57%. Hasil uji Skrining fitokimia pada ekstrak etanol 96% daun cabai rawit (Capsiccum frutescens L.) menunjukkan bahwa ekstrak etanol 96% daun cabai rawit mengandung alkaloid, saponin, tannin, terpenoid dan…
creator: Annisa Nismaul Husna
creator: Onny Ziasti Fricillia
creator: Rolan Rusli
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 187
ending page: 191
doi: 10.25026/mpc.v18i1.725

Skrining Fitokimia dan Uji Aktivitas Tabir Surya Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.)
type: item
description: Rambutan (Nephelium lappaceum L.) is a tropical plant that is widely found in Indonesia and can be used as sunscreen to protect the skin from UV radiation. The purpose of this study was to determine the content of secondary metabolite compounds and the sunscreen activity of rambutan leaf extract. Phytochemical screening results show that rambutan leaf extract contains flavonoids tannins and saponins, Rambutan leaf extract 100 ppm has sunscreen activity in the sunblock category with a %Te value of 0,58 and %Tp 31,28; and an SPF value of 23,09, including the ultra protection category. Keywords: Rambutan leaf, Phytochemical, Sunscreen Abstrak Rambutan (Nephelium lappaceum L.) merupakan tanaman tropis yang banyak terdapat di Indonesia yang dapat dimanfaatkan sebagai tabir surya untuk melindungi kulit dari radiasi sinar UV. Tujuan dari penelitian ini adalah untuk mengetahui kandungan senyawa metabolit sekunder dan aktivitas tabir surya ekstrak daun rambutan. Hasil skrinning fitokimia menunjukkan bahwa ekstrak daun rambutan mengandung senyawa flavonoid, tannin, dan saponin. Ekstrak daun rambutan 100 ppm memiliki aktivitas tabir surya kategori sunblock dengan nilai %Te 0,58 dan %Tp 31,28; dan nilai SPF sebesar 23,09 termasuk kategori proteksi ultra. Kata Kunci: Daun Rambutan, Fitokimia, Tabir surya
creator: Ayu Lestari
creator: Rolan Rusli
creator: Fika Aryati
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 192
ending page: 198
doi: 10.25026/mpc.v18i1.726

Level of Knowledge, Attitudes and Behavior towards Antibiotic Resistance and Use in The Community in Kota Bangun Seberang Village
type: item
description: Antibiotics are highly used drugs in Indonesia to treat infections. However, low public knowledge about antibiotics leads to their inappropriate use. Inappropriate use of antibiotics will eventually increase health problems in the form of resistance. This study aims to determine the level of knowledge, attitudes and behavior towards resistance and the use of antibiotics in the community in Kota Bangun Seberang. The method used in this research is observational analysis with cross sectional study approach. Data collection was conducted by interviews using questionnaires consisting of questions about resistance and antibiotic use. Sample collection of 80 people using purposive sampling technique. Data were analyzed univariately and bivariately using the Spearman correlation test. The results showed that the majority of respondents' knowledge level was in the good category at 55%, the majority of respondents' attitudes were in the moderate category at 47.5%, and the majority of respondents' behavior was in the good category at 51.25%. Spearman correlation test showed that there was no correlation between the level of knowledge and attitude, as well as the relationship between attitude and behavior of respondents regarding antibiotic resistance and use (sig > 0.01), and there was a very strong positive correlation between the level of knowledge and antibiotic use behavior of respondents (sig < 0.01).
creator: Riska Febriyanti
creator: Nur Masyithah Zamruddin
creator: Adam M. Ramadhan
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 199
ending page: 209
doi: 10.25026/mpc.v18i1.693

Laporan Kasus: Epilepsi pada Wanita Muda
type: item
description: Epilepsy is a chronic disorder of the brain characterized by recurrent seizures caused by excessive electrical discharges in a group of nerve cells. Epilepsy is one of the causes of morbidity that can attack all ages. This disease can reduce the quality of life for sufferers. It estimated that around 50 million people suffer from epilepsy in the world, and 80% of the total sufferers come from developing countries. Seizures occur due to excessive excitation or due to irregular inhibition of neurons. This case report concerns female epileptic patient (14 year old) in outpatient treatment. The patient received anti-epileptic drug therapy (AED), namely Depakote, Folic Acid and Kutoin. The therapy had given can control the patient's seizure condition for three years without any side effects or adverse drug reactions. Keywords: Epilepsy, Management, Anti-Epileptic Drugs (AED) Abstrak Epilepsi adalah kelainan kronis pada otak yang ditandai dengan kejang berulang akibat pelepasan muatan listrik yang berlebihan pada sekelompok sel saraf. Epilepsi menjadi salah satu penyebab morbiditas yang dapat menyerang semua umur. Penyakit ini dapat menurunkan kualitas hidup bagi penderita. Diduga terdapat sekitar 50 juta orang menderita epilepsi didunia, dan 80% dari total penderita berasal dari negara berkembang. Kejang terjadi akibat eksitasi yang berlebihan atau akibat penghambatan neuron yang tidak teratur. Laporan kasus ini mengenai kejadian epilepsi pada pasien wanita berusia 14 tahun di pengobatan rawat jalan. Pasien mendapatkan terapi obat anti epilepsi (OAE) yaitu Depakote, Asam Folat dan Kutoin. Terapi yang diberikan dapat mengendalikan kondisi kejang pasien selama 3 tahun tanpa adanya efek samping atau reaksi obat yang merugikan. Kata Kunci: Epilepsi, Tatalaksana, Obat Anti Epilepsi (OAE)
creator: Noviyanty Indjar Gama
creator: Dinda Tri Rahayu
creator: Fridya Maulitha
creator: Novia Anggriani
creator: Rizky Mulyaramadhan
creator: Zulianita Zulianita
creator: Falda Gizella Mangnga
creator: Ratna Aprilia Sari
creator: Yuliana Megi Pasudi
rights: Copyright (c) 2023 Proceeding of Mulawarman Pharmaceuticals Conferences https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2023-12-31
publication date: 2023-12-31
volume: 18
starting page: 211
ending page: 214
doi: 10.25026/mpc.v18i1.728